By using sequencing results from a cohort of 1,054 patients with advanced lung adenocarcinomas, we developed OncoCast, a machine learning tool for survival risk stratification and biomarker identification. We found that comutations of both STK11 and KEAP1 are strong determinants of unfavorable prognosis with currently available therapies.
This novel study suggests that polymorphisms in genes involved in aging and inflammation, dopamine, myelin and cell cycle regulation, and DNA repair and response to oxidative stress may be associated with cognitive outcome in patients with brain tumors.
Utilizing a recently published dog Y-chromosome reference, we analyzed Y-chromosome sequence across a diverse collection of canids and determined the Y haplogroup of three ancient European dogs. We estimate that the time to the most recent comment ancestor of dog Y haplogroups is 68–151 thousand years ago and confirm long-standing population structure among European dogs.